Please ensure Javascript is enabled for purposes of website accessibility Profile - BARTHOLOMEW N ONDIGO
Back
Upload

BARTHOLOMEW N ONDIGO

OffLine
Staff Information
PERSONAL DETAILS
Designation
SENIOR LECTURER
Corporate Email
This email address is being protected from spambots. You need JavaScript enabled to view it.
Job Category
Teaching
Phone Number
+254051-2217891
Division / Faculty
Faculty of Science
Directorate / Dept
DEPT. OF BIOCHEMISTRY & MOLECULAR BIO
ACADEMIC QUALIFICATIONS
  • Ph.D. Biomedical Sciences
  • MSc. Biomedical Sciences
  • BSc. Biomedical Sciences
WORK EXPERIENCE

2015- to date: Lecturer (Egerton University)

  • Chairperson, Departmental Postgraduate Research Committee and Member Faculty of Science Postgraduate Committee (2015 – 2019)
  • Team leader, Bachelor of Science (Biomedical Science and Technology) Curriculum Review (2015 – 2019)
  • Academic advising and student mentoring (2015 – to date)
  • Teaching undergraduate and postgraduate students
  • Carrying out research in biomedical research

2012- 2014: Assistant Lecturer (Laikipia University)

2009 - 2011: Part-time (Maseno/JKUAT/Kisii/JOOUST/Moi universities

RESEARCH INTERESTS
  • Host-pathogen interactions
  • Mechanisms of immunity and correlates of protection
  • Global health
LIST OF PUBLICATIONS

2023

1. Oduma CO, Ombok M, Zhao X, Huwe T, Ondigo BN, Kazura JW, Grieco J, Achee N, Liu F, Ochomo E, Koepfli C. Altitude, not potential larval habitat availability, explains pronounced variation in Plasmodium falciparum infection prevalence in the western Kenya highlands. PLOS Glob Public Health. 2023;3(4):e0001505 https://pubmed.ncbi.nlm.nih.gov/37068071/

2. Gibbs LC, Oviedo JM, Ondigo BN, Fairfax KC. Maternal infection causes dysfunctional BCR signaling in male offspring due to aberrant Xist expression. bioRxiv. 2023:2023.02.13.528357 https://pubmed.ncbi.nlm.nih.gov/36824836/

 

2022

3. Wakoli DM, Ondigo BN, Ochora DO, Amwoma JG, Okore W, Mwakio EW, Chemwor G, Juma J, Okoth R, Okudo C, Yeda R, Opot BH, Cheruiyot AC, Juma D, Roth A, Ogutu BR, Boudreaux D, Andagalu B, Akala HM.  Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs. BMC Med. 2022;20(1):448. https://pubmed.ncbi.nlm.nih.gov/36397090/

4. Ondigo BN, Hamilton RE, Magomere EO, Onkanga IO, Mwinzi PN, Odiere MR, Ganley-Leal L. Potential Utility of Systemic Plasma Biomarkers for Evaluation of Pediatric Schistosomiasis in Western Kenya. Front Immunol. 2022;13:887213 https://pubmed.ncbi.nlm.nih.gov/35603171/

5. Onkanga IO, Hamilton R, Mwinzi PNM, Schneider T, Ondigo BN, Sang H, Ondari E, Rawago F, Jaoko W, Odiere MR, Ganley-Leal L. Expression of CD117 (c-Kit) on Circulating B Cells in Pediatric Schistosomiasis. Infect Immun. 2022 Aug 18;90(8):e0016022. https://pubmed.ncbi.nlm.nih.gov/35862720/

6. Dumre SP, LaBeaud AD, Ehrlich H, Vazquez Guillamet LJ, Ondigo BN, Sadarangani SP, Wamae CN, Whitfield K. Why Climate Action Is Global Health Action. American Society of Tropical Medicine and Hygiene (ASTMH) Green Task Force members;  Am J Trop Med Hyg. 2022;107(3):500-3 https://pubmed.ncbi.nlm.nih.gov/35895350/

 

2021

7. Mutuku CN, Bateta R, Rono MK, Njunge JM, Awuoche EO, Ndung'u K, Mang'era CM, Akoth MO, Adung'a VO, Ondigo BN, Mireji PO. Physiological and proteomic profiles of Trypanosoma brucei rhodesiense parasite isolated from suramin responsive and non-responsive HAT patients in Busoga, Uganda. Int J Parasitol Drugs Drug Resist. 2021;15:57-67. https://pubmed.ncbi.nlm.nih.gov/33588295/

8. Oduma CO, Ogolla S, Atieli H, Ondigo BN, Lee MC, Githeko AK, Dent AE, Kazura JW, Yan G, Koepfli C. Increased investment in gametocytes in asymptomatic Plasmodium falciparum infections in the wet season. BMC Infect Dis. 2021;21(1):44. https://pubmed.ncbi.nlm.nih.gov/33422001/

 

2020

9. Ondigo BN, Hamre KES, Frosch AEP, Ayodo G, White MT, John CC. Antibody Profiles to P. falciparum antigens over time characterize acute and long-term malaria exposure in an area of low and unstable transmission. Am J Trop Med Hyg. 2020;103(6):2189-2197. https://pubmed.ncbi.nlm.nih.gov/33124539/

10. Hamre KES, Ondigo BN, Hodges JS, Dutta S, Theisen M, Ayodo G, John CC. Antibody correlates of protection from clinical Plasmodium falciparum malaria in an area of low and unstable malaria transmission. Am J Trop Med Hyg. 2020;103(6):2174-2182. https://pubmed.ncbi.nlm.nih.gov/33124533/

11. Abudho BO, Guyah B, Ondigo BN, Ndombi EM, Ireri E, Carter JM, Riner DK, Kittur N, Karanja DMS, Colley DG. Evaluation of morbidity in Schistosoma mansoni-positive primary and secondary school children after four years of mass drug administration of praziquantel in western Kenya. Infect Dis Poverty. 2020; 9(1): 67. https://pubmed.ncbi.nlm.nih.gov/32539826/

12. Chege NM, Ondigo BN, Onyambu FG, Kattam AM, Lagat N, Irungu T, Matey EJ. The prevalence of intestinal parasites and associated risk factors in school-going children from informal settlements in Nakuru town, Kenya. Malawi Med J. 2020; 32 (2) 80 -  86. https://www.ajol.info/index.php/mmj/article/view/197193

13. Oduma CO, Ondigo BN, Kimotho JH. Codon 249 P53 Gene Mutation Among Hepatocellular Carcinoma Patients In western Kenya. OAJBS. 2020; 1(4). https://biomedscis.com/fulltext/codon-249-p53-gene-mutation-among-hepatocellular-carcinoma-patients-in-western-kenya.ID.000136.php

14. Ondigo BN. Road map for capacity building and development for biomedical sciences in Kenya. Pan Afr Med J. 2020; 35: 94. https://pubmed.ncbi.nlm.nih.gov/32636992/

 

2019

15. Odhiambo EO, Datta D, Guyah B, Ayodo G, Ondigo BN, Abong'o BO, John CC, Frosch AEP. HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in western Kenya. Malar J. 2019; 18(1):297. https://pubmed.ncbi.nlm.nih.gov/31470903/

16. Magomere EO, Nyangahu DD, Kimoloi S, Webala BA, Ondigo BN. Performance characteristics of a modified HIV-1 drug resistance genotyping method for use in resource-limited settings. F1000Res. 2019;8:1518. https://pubmed.ncbi.nlm.nih.gov/31656591/

17. Ondigo BN, Park GS, Ayieko C, Nyangahu DD, Wasswa R, John CC. Comparison of non-magnetic and magnetic beads multiplex assay for assessment of Plasmodium falciparum PeerJ. 2019;7:e6120. https://pubmed.ncbi.nlm.nih.gov/30627487/

 

2018

18. Korir HK, Riner DK, Kavere E, Omondi A, Landry J, Kittur N, Ndombi EM, Ondigo BN, Secor WE, Karanja DMS, Colley DG. Young adults in endemic areas: An untreated group in need of school-based preventive chemotherapy for schistosomiasis control and elimination. Trop Med Infect Dis. 2018;3(3):100. https://pubmed.ncbi.nlm.nih.gov/30274496/

19. Ondigo BN, Muok EMO, Oguso JK, Njenga SM, Kanyi HM, Ndombi EM, Priest JW, Kittur N, Secor WE, Karanja DMS, Colley DG. Impact of mothers' Schistosomiasis Status During Gestation on Children's IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western Kenya. Front Immunol. 2018;9:1402. https://pubmed.ncbi.nlm.nih.gov/29967622/

20. Ondigo BN, Ndombi EM, Nicholson SC, Oguso JK, Carter JM, Kittur N, Secor WE, Karanja DMS, Colley DG. Functional Studies of T Regulatory Lymphocytes in Human Schistosomiasis in Western Kenya. Am J Trop Med Hyg. 2018; 98(6):1770-1781. https://pubmed.ncbi.nlm.nih.gov/29692308/

 

2017

21. Frosch AE, Odumade OA, Taylor JJ, Ireland K, Ayodo G, Ondigo B, Narum DL, Vulule J, John CC. Decrease in Numbers of Naive and Resting B Cells in HIV-Infected Kenyan Adults Leads to a Proportional Increase in Total and Plasmodium falciparum-Specific Atypical Memory B Cells. Immunol. 2017;198(12):4629-4638. https://pubmed.ncbi.nlm.nih.gov/28526680/

 

2015

22. Noland GS, Jansen P, Vulule JM, Park GS, Ondigo BN, Kazura JW, Moormann AM, John CC. Effect of transmission intensity and age on subclass antibody responses to Plasmodium falciparum pre-erythrocytic and blood-stage antigens. Acta Trop. 2015;142:47-56. https://pubmed.ncbi.nlm.nih.gov/25446174/

 

2014

23. Ondigo BN, Hodges JS, Ireland KF, Magak NG, Lanar DE, Dutta S, Narum DL, Park GS, Ofulla AV, John CC. Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum J Infect Dis. 2014;210 (7):1123-1132. https://pubmed.ncbi.nlm.nih.gov/24737801/

24. Frosch AE, Ondigo BN, Ayodo GA, Vulule JM, John CC, Cusick SE. Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya. Am J Clin Nutr. 2014;100(3):968-973. https://pubmed.ncbi.nlm.nih.gov/25080460/

 

2013

25. Ochola LA, Ng'wena GM, Noland GS, Ondigo BN, Ayodo G, John CC. The Plasmodium falciparum Antigen MB2 Induces Interferon-γ and Interleukin-10 Responses in Adults in Malaria Endemic Areas of Western Kenya. J Glob Infect Dis. 2013;5(4):131-137. https://pubmed.ncbi.nlm.nih.gov/24672173/

26. Kimoloi S, Okeyo N, Ondigo BN, Langat, BL. Choice and Sources of Antimalarial Drugs Used for Self-medication in Kisumu, Western Kenya. Afr J for Pharm and Therap. 2013;2(4). http://journals.uonbi.ac.ke/ajpt/article/view/1176

 

2012

27. Ondigo BN, Park GS, Gose SO, Ho BM, Ochola LA, Ayodo GO, Ofulla AV, John CC Standardization and validation of a cytometric bead assay to assess antibodies to multiple Plasmodium falciparum recombinant antigens. Malar J. 2012;11:427. https://pubmed.ncbi.nlm.nih.gov/23259607/

 

2009

28. Use of recombinant protein fragments from Mycoplasma mycoides subsp mycoides SC type to improve contagious bovine pleuropneumonia (CBPP) T cell and antibody-based assays. Kenya Veterinary Journal.

CONFERENCES & INVITED PRESENTATIONS
  1. Ondigo, B.N., Moore I.N., Ganesan, S., Bock, K.W., Blank, P.S., Mahamar, A., Attaher, O., Diarra, B.S., Sidibe, Y., Neal, J., Dicko, A., Duffy, P.E., and Fried, M., “CD163 gene expression and soluble CD163 levels increase in malaria-infected pregnant women.” AMER SOC TROP MED & HYGIENE, 2020 pp. 266.
  2. Odhiambo, E. O., Datta, D., Guyah, B., Ondigo, B. N., Ayodo, G., Abong'o, B. O., and Frosch, A. E. “Antibody responses to Plasmodium falciparum antigens in human immunodeficiency virus-infected adults in Bondo sub-county hospital, western Kenya.” AMER SOC TROP MED & HYGIENE, 2017 pp. 376.
  3. Sang, H., Hamilton, R., Onkanga, I., Ondigo B. N., Schneider, T., Odiere, M., Mwinzi, P.N.M., and Ganley-Leal, L., "Dichomotous effects of IL-4 and IL-10 on human schistosomiasis immune responses.” AMER SOC TROP MED & HYGIENE, 2017 pp. 624.
  4. Onkanga, I. O., Sang, H., Ondigo, B.N., Hamilton, R., Schneider, T., Odiere, M., Mwinzi, P.N.M., and Ganley-Leal. L., "Identification of a CD193+ subpopulation of a B cells in Pre-Adolescent children with schistosomiasis”, AMER SOC TROP MED & HYGIENE. 2017 pp.184.
  5. Hamre, K.E., Ondigo B.N., Ayodo, G., Vulule, J., and John C. C. "Associations of antibody responses the protection from clinical malaria in a highland Kenya area of low transmission." AMER SOC TROP MED & HYGIENE, 2015. pp. 98
HONORS, PRIZE AND AWARDS
  1. African Postdoctoral Training Initiative Fellowship
  2. Global Health Fellowship
  3. ASTMH Travel Award
  4. Ph.D. Fellowship
  5. Biosciences eastern and central Africa (BecA) Masters Fellowship
TEACHING AREAS
  • Introduction to biomedical science and technology
  • Medical histology
  • Parasitology
  • Biochemical techniques and instrumentation
POSTGRADUATE SUPERVISION
MASTERS LEVEL :

Completed

  1. Edwin Magomere - Characterization of HIV drug resistance mutations and subtype diversity of isolates from children and adolescents failing viral suppression in Kenyatta National Hospital. (University of Nairobi/Egerton University) 
  2. Colins Oduma - Molecular analysis of P53 gene exon 7 codon 249 mutations in hepatocellular carcinoma patients presenting at Moi Teaching and Referral Hospital, Kenya. (KEMRI/Egerton University) 
  3. Harrison Korir - Intensity of Schistosoma mansoni infections and anti-schistosome antibody responses among students from Kisumu National Polytechnic in Kisumu county, western Kenya. (KEMRI/Maseno University)
  4. Naomi Chege - Prevalence and risk factors associated with intestinal parasites among school-going children from informal settlements of Nakuru town, Kenya. (KEMRI/Egerton University)
  5. Catherine Mutuku - Physiological and proteomic profiles of Trypanosoma brucei rhodesiense parasite isolated from suramin responsive and non-responsive HAT patients in Busoga, Uganda (KARI/Egerton University) 

Ongoing

6. Duncan Wakoli - Investigation of Plasmodium falciparum piperaquine resistance using molecular marker analyses and growth inhibition assays in Kenya (United States Army Medical Research/KEMRI/Egerton University) - Thesis defended and awaiting graduation

7. Dickson Kipchirchir - Specificity and sensitivity of microscopy and malaria rapid diagnostic kit compared to quantitaive PCR amongst pregnanct women presenting for delivery in Busia county, Kenya (KEMRI/JKUAT) - Proposal defended at the department. 

8.  Evelyne Chimwani - Determinants of optimal intermittent preventative malaria therapy and insecticide- treated net usage among pregnant women, Busia, Kenya (KEMRI/JOOUST)

PhD. LEVEL :

 Completed

  1. Colins Oduma - Impact of seasonality and multiplicity of Plasmodium falciparum infection on patterns of gametocyte among malaria asymptomatic individuals from selected sites in western Kenya. (Case Western University/University of Notre Dame/KEMRI/Egerton University) 
OTHER SOCIETIES
  1. Kenya Society of Immunology
  2. Biomedical Society of Kenya
  3. American Society of Tropical Medicine and Hygiene
  4. Royal Society of Tropical Medicine and Hygiene
Copyright © 2024 Egerton University
"Transforming Lives through Quality Education"